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Radiation therapy will have a negative effect on the body and some of the side effects of radiation include: A sore throat or mouth Dry mouth and loss of salivary gland function Tooth decay Nausea and vomiting Sore or bleeding gums Skin and mouth infections Jaw stiffness and pain Problems wearing dentures Fatigue A change in your ability to taste and smell Changes in your skin, including dryness and burning Weight loss Thyroid changes While Chemotherapy drugs are effective in destroying the cancer cells in the mouth but they are also very toxic to the noncancerous cells and this can cause side effects such as: Hair loss Painful mouth and gums Bleeding in the mouth Severe anemia Weakness Poor appetite Nausea Vomiting Diarrhea Mouth and lip sores Numbness in the hands and feet Recovering from targeted therapies is usually minimal